Researchers have announced the most promising experimental vaccine to date
to protect infants and young children against malaria. Investigators say the
candidate vaccine will begin its final regulatory hurdle next year.
In two studies published in The New England Journal of Medicine,
researchers report the results of two clinical trials in Kenya and Tanzania of
the experimental malaria vaccine, RTS, S/AS.
Investigators found the vaccine, which is the most clinically advanced to date,
prevented the disease in more than half of babies and young children in the
studies. Malaria kills some one million people each year, most of them in
Christian Loucq is Director of the PATH Malaria Vaccine Initiative, a
non-profit research funding organization. Loucq says that while the candidate
vaccine is not perfect, it is a step in the right direction.
"The research results reported today show that we are one important step
closer to the day when malaria will join diseases like smallpox and polio that
have been either eradicated or controlled by vaccine."
In the study in Tanzania, researchers gave the vaccine to 340 infants. They say
that 65 percent of them were protected against malaria during the six month
In Kenya, which enrolled almost 900 children between five and seventeen months
old, RTS, S/AS protected 53 percent of them over an eight month period.
Ripley Ballou is with the Bill and Melinda Gates Foundation of the U.S., which
promotes global health, development and education. He says “Researchers are now
recruiting 16-thousand infants and young children to begin final phase clinical
trials next year. It all goes well, they are expected to seek regulatory
approval in 2011.”
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Translated by Buasawan Simmala